Principal/Senior Data Scientist

One Nucleus Limited
Cambridge
2 days ago
Create job alert

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenges.

We are hiring a Senior Data Scientist/Principal Data Scientist to join our interdisciplinary team at the forefront of computational biology and AI for a 2 year fixed term contract. You will contribute to (lead - principal data scientist) transformative projects that integrate single-cell genomics, spatial transcriptomics, and generative AI to build next-generation models for understanding tissue biology and cellular dynamics across organs such as the pancreas, kidney, skin, and liver.

Available Research Focus Areas

  • Spatial & Multi-omics Atlas Construction Build large-scale spatial and single-cell atlases across diseased tissues (pancreas, kidney, skin, liver) using spatial transcriptomics, scRNA-seq, and multiome data in collaboration with leading Sanger groups.
  • Generative AI for Cell Fate & Perturbations Develop diffusion, flow-matching, and transformer-based generative models to predict cell fate, tissue remodelling, and drug or perturbation responses in silico.
  • Foundational Models for Single-Cell Biology Train large, generalizable deep models across public and internal datasets to support the Human Cell Atlas and broad Sanger research programs.
  • Open Targets Translational AI Projects Apply foundational and multi-omics models to real-world challenges in drug discovery, target identification, and target safety in collaboration with major pharma partners.
  • Agentic AI for Scientific Reasoning & Experiment Design (new) Develop AI agents capable of hypothesis generation, experiment planning, and multi-step scientific workflows using reinforcement learning and tool-use models.
  • Core Machine Learning Research Advance fundamental ML methods—including advanced generative modelling, scalable training algorithms, representation learning, and uncertainty modelling—tailored for biological data.
  • Multimodal Learning (Imaging + Genomics + Clinical Data) Create models that integrate histopathology imaging, spatial proteomics, single-cell genomics, and patient-level clinical data to learn unified biological and clinical representations
  • Leap Project - We are interested in developing large-scale AI models to stratify patients using diverse multi-omics data, with a strong commitment to equity and inclusion, particularly in women’s health. This work is being undertaken in collaboration with Roser Vento-Tormo at the Sanger Institute

The Open Targets (OT) research programme generates and analyses data to connect targets to diseases, assess the strength of this evidence, and help identify and prioritise targets for drug discovery. This includes evidence that causally links targets and diseases, as well as foundational data that helps us understand biological processes and disease progression more deeply.

Salary per annum (dependent upon skills and experience):

Please submit your CV and a cover letter detailing your research experience, interest in the focus area(s), and future aspirations.


#J-18808-Ljbffr

Related Jobs

View all jobs

Principal/Senior Data Scientist

Principal/Senior Data Scientist

Principal Data Scientist — Hybrid AI for Single-Cell Bio

Senior Data Scientist

Senior Data Scientist

Senior Data Scientist

Subscribe to Future Tech Insights for the latest jobs & insights, direct to your inbox.

By subscribing, you agree to our privacy policy and terms of service.

Industry Insights

Discover insightful articles, industry insights, expert tips, and curated resources.

The Skills Gap in Data Science Jobs: What Universities Aren’t Teaching

Data science has become one of the most visible and sought-after careers in the UK technology market. From financial services and retail to healthcare, media, government and sport, organisations increasingly rely on data scientists to extract insight, guide decisions and build predictive models. Universities have responded quickly. Degrees in data science, analytics and artificial intelligence have expanded rapidly, and many computer science courses now include data-focused pathways. And yet, despite the volume of graduates entering the market, employers across the UK consistently report the same problem: Many data science candidates are not job-ready. Vacancies remain open. Hiring processes drag on. Candidates with impressive academic backgrounds fail interviews or struggle once hired. The issue is not intelligence or effort. It is a persistent skills gap between university education and real-world data science roles. This article explores that gap in depth: what universities teach well, what they often miss, why the gap exists, what employers actually want, and how jobseekers can bridge the divide to build successful careers in data science.

Data Science Jobs for Career Switchers in Their 30s, 40s & 50s (UK Reality Check)

Thinking about switching into data science in your 30s, 40s or 50s? You’re far from alone. Across the UK, businesses are investing in data science talent to turn data into insight, support better decisions and unlock competitive advantage. But with all the hype about machine learning, Python, AI and data unicorns, it can be hard to separate real opportunities from noise. This article gives you a practical, UK-focused reality check on data science careers for mid-life career switchers — what roles really exist, what skills employers really hire for, how long retraining typically takes, what UK recruiters actually look for and how to craft a compelling career pivot story. Whether you come from finance, marketing, operations, research, project management or another field entirely, there are meaningful pathways into data science — and age itself is not the barrier many people fear.

How to Write a Data Science Job Ad That Attracts the Right People

Data science plays a critical role in how organisations across the UK make decisions, build products and gain competitive advantage. From forecasting and personalisation to risk modelling and experimentation, data scientists help translate data into insight and action. Yet many employers struggle to attract the right data science candidates. Job adverts often generate high volumes of applications, but few applicants have the mix of analytical skill, business understanding and communication ability the role actually requires. At the same time, experienced data scientists skip over adverts that feel vague, inflated or misaligned with real data science work. In most cases, the issue is not a lack of talent — it is the quality and clarity of the job advert. Data scientists are analytical, sceptical of hype and highly selective. A poorly written job ad signals unclear expectations and immature data practices. A well-written one signals credibility, focus and serious intent. This guide explains how to write a data science job ad that attracts the right people, improves applicant quality and positions your organisation as a strong data employer.