Principal Statistician

Barrington James
London
6 days ago
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Principal Statistician – Evidence Synthesis & HTA

Location: Oxfordshire or London


Sector: HEOR / Evidence Synthesis / HTA


Type: Permanent, full-time


Our client is seeking a Principal Statistician to lead complex evidence‑synthesis programmes and guide statistical strategy across high‑impact HTA and market access projects. This role offers substantial influence, technical leadership, and the opportunity to shape methodologies within a collaborative, methodologically focused team.


The Role

As a Principal Statistician, you will own the design, delivery, and interpretation of statistical components across multiple evidence‑synthesis and HTA projects. You will partner closely with multidisciplinary teams while providing direction and mentorship for developing statisticians.


Key Responsibilities

  • Design statistical analysis plans and feasibility assessments for advanced evidence‑synthesis challenges.
  • Code and run analyses including pairwise meta‑analysis, NMAs (including time‑varying survival models), MAIC/PAIC, and individual patient data analyses.
  • Oversee quality control processes to ensure methodological rigour and reproducibility.
  • Communicate complex statistical results clearly to clients and cross‑functional teams.
  • Lead contributions to proposals, pitch presentations, and development of internal methodologies, SOPs, and QC frameworks.
  • Provide technical leadership, coaching, and mentorship to junior and mid‑level statisticians.

About You

You bring depth of experience in evidence synthesis and thrive in roles that blend analytical excellence, leadership, and intellectual ownership. You enjoy shaping projects, influencing decision‑making, and raising the statistical bar within a team.


Essential Experience

  • Master’s degree or PhD in a quantitative discipline.
  • Significant experience leading evidence‑synthesis statistical work (meta‑analysis, NMA, indirect comparisons).
  • Proficiency in R, with familiarity in Bayesian approaches (e.g., BUGS).
  • Strong track record in HTA‑focused analyses and interpreting results for health economic models and submissions.
  • Experience leading or mentoring statisticians and influencing analytical approaches.
  • Clear and confident communication of complex statistical concepts to diverse audiences.

Desirable

  • Experience with advanced NMA developments (e.g., ML‑NMR).
  • Experience delivering training or statistical learning initiatives.
  • Consultancy experience managing multiple projects simultaneously.

What’s On Offer

You’ll join a supportive, engaging environment where quality, curiosity, and development are central. Expect:



  • A flexible working culture with genuine autonomy.
  • Regular interaction with senior leadership and the chance to shape internal methodologies.
  • Broad exposure across therapeutic areas and diverse HTA‑focused projects.
  • The influence and visibility expected of a true Principal‑level role.


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