Isomorphic Labs

• London
• Hybrid · 3 days in office
• Lead

Design and evolve a large-scale ML infrastructure platform that supports distributed training and inference workloads, working closely with research, engineering and product teams. The role also explores deploying agents to improve platform robustness and reliability, in a hybrid London setting.

Kubernetes · Google Cloud Platform · GCP

• London
• Hybrid · 3 days in office
• Lead

Lead medicinal chemistry strategy across drug discovery programmes, from hit identification through lead optimisation to candidate nomination, while working hands-on as an individual contributor. Partner closely with AI/ML platform teams to refine predictive models and manage CRO resources, mentoring junior colleagues in a hybrid London team.

AlphaFold

• London
• Hybrid · 3 days in office
• Senior · manages people

Lead computational chemistry strategy across drug discovery programs, applying AI-first methods to hit finding, molecular design and lead optimisation. Work with ML scientists to embed generative models and ultra-large virtual screening into workflows, with optional line management of 2-3 computational chemists.

REINVENT · AlphaFold · Large Language Models +2

• London
• Hybrid · 3 days in office
• Lead

Drive DMPK strategy across drug discovery projects, designing screening cascades and mechanistic experiments with an AI-first approach. Integrate DMPK, PD and toxicology data to predict human dose and safety windows, and author regulatory documents. Work closely with Chemistry, Pharmacology and AI/ML platform teams in a hybrid London setting.

R · Python · KNIME

• London
• Hybrid · 3 days in office
• Lead

Lead (pre)-formulation strategy for small molecules across drug discovery and preclinical development, designing technologies such as solid dispersions and co-crystals to improve solubility, stability and manufacturability. Interpret stability studies using ICH and ASAP methods, author regulatory submissions, and work with drug design, preclinical and CMC teams while managing external CRO resources.

ICH · ASAP · FDA

• London
• Hybrid · 3 days in office
• Senior

Lead pharmacology and translational biology strategy for large molecule therapeutics, designing in vivo and in vitro studies and acting as Biology Lead on drug discovery projects. Coordinate internal workflows and external CROs to drive candidates toward go/no-go decisions, while feeding pharmacology data back into generative AI design loops.

Generative AI · AlphaFold