We are seeking a Genomic Data Scientist to join our Bioinformatics Consulting team to work on a range of genome analysis and interpretation projects with an emphasis in rare or complex disease in collaboration with and on behalf of our external researchers and industrial partners.
In this role you will work as part of multidisciplinary teams to develop and execute cutting edge projects that leverage Genomics England datasets to address research goals such as drug target identification biomarker discovery diagnostic discovery and patient stratification.
You will contribute to the scoping implementation and application of stateoftheart approaches for analysis of genomic and other omics modalities in both leading and supporting capacity. As an expert user of our datasets and research environment you will develop and finetune tools and pipelines to perform custom computational analyses generate new data and contribute to high quality reports and documentation.
Everyday responsibilities include:
- Preparing data for downstream analysis e.g. through quality control functional annotation aggregation harmonisation across different datasets.
- Planning and supporting analyses to meet project objectives with internal teams and external stakeholders. Providing support to internal teams and collaborators and being the point of reference for genomic datasets and analytical approaches.
- Performing custom computational analyses on whole genome sequencing and other omics data such as GWAS aggregate variant testing metaanalysis differential abundance finemapping and MR.
- Researching the scientific literature identifying new approaches to processing and analysis of genomics and multiomics data benchmarking and improving tools.
- Contributing to the publication and dissemination of findings via scientific papers white papers and conference presentations.
Skills and Experience for Success:
- Strong programming skills (R Python)and solid background of statistical genetics.
- Demonstrable experience using whole genome sequencing data in the context of human genetics.
- Strong background in human disease genetics preferably in rare or complex disease demonstrated by publication record or industry track record.
- Demonstrable experience with at least one additional omics modality (e.g. long read sequencing single cell transcriptomics proteomics metabolomics).
- Proven track record in one or more areas of human germline DNA analysis such as genetic association testing population genetics pharmacogenomics rare disease genomics structural variation analysis working with complex genomic regions such as HLA/KIR/PGx.
- Experience with working in the cloud building containers and running pipelines in nextflow.
- Proven ability to communicate with stakeholders from diverse backgrounds IT R&D biology bioinformatics) and keep track of customer relationships and a clear understanding of clinical and phenotypic data management and the sensitivities surrounding patient cohort data.
- Excellent interpersonal skills attention to detail selfmotivation collaborative and delivery mindset
Qualifications :
A PhD involving one of the following: Statistical or Computational Genetics Biostatistics Population Genetics or equivalent quantitative discipline.
Additional Information :
Salary from 55000
Being an integral part of such a meaningful mission is extremely rewarding in itself but in order to support our people were continually improving our benefits package. We pride ourselves on investing in our people and supporting them to achieve their career goals as well as offering a benefits package including:
- Generous Leave:30 days holiday plus bank holidays additional leave for long service and the option to apply for up to 30 days of remote working abroad annually (approval required).
- FamilyFriendly:Blended working arrangements flexible working enhanced maternity paternity and shared parental leave benefits.
- Pension & Financial:Defined contribution pension (Genomics England doublematches up to 10 however you can contribute more if you wish) Life Assurance 3x salary) and a Give As You Earn scheme.
- Learning & Development:Individual learning budgets support for training and certifications and reimbursement for one annual professional subscription (approval required).
- Recognition & Rewards:Employee recognition programme and referral scheme.
- Health & Wellbeing:Subsidised gym membership a free Headspace account and access to an Employee Assistance Programme eye tests flu jabs.
Equal opportunities and our commitment to a diverse and inclusive workplace
Genomics England is actively committed to providing and supporting an inclusive environment that promotes equity diversity and inclusion best practice both within our community and in any other area where we have influence. We are proud of our diverse community where everyone can come to work and feel welcomed and treated with respect regardless of any disability ethnicity gender gender identity religion sexual orientation or social background.
Genomics Englands policies of nondiscrimination and equity and will be applied fairly to all people regardless of age disability gender identity or reassignment marital or civil partnership status being pregnant or recently becoming a parent race religion or beliefs sex or sexual orientation length of service whether full or parttime or employed under a permanent or a fixedterm contract or any other relevant factor.
Genomics England does not tolerate any form of discrimination harassment victimisation or bullying at work. Such behaviour is contrary toour virtues undermines our mission and core values and diminishes the dignity respect and integrity of all parties. Our People policies outline our commitment to inclusivity.
We aim to remove barriers in our recruitment processes and to be flexible with our interview processes. Should you require any adjustments that may help you to fully participate in the recruitment process we encourage you to discuss this with us.
Blended working model
Genomics England operates a blended working model as we know our people appreciate the flexibility that hybrid working can bring. We expect most people to come into the office a minimum of 2 times each month. However this will vary according to role and will be agreed with your team leader. There is no expectation that people will return to the office full time unless they want to however some of our roles require full time on site attendance e.g. lab teams reception team.
Our teams and squads have and will continue to reflect on what works best for them to work together successfully and have the freedom to design working patterns to suit beyond the minimum. Our office locations are: Canary Wharf Cambridge and Leeds.
Onboarding background checks
As part of our recruitment process all successful candidates are subject to a Standard Disclosure and Barring Service (DBS) check. We therefore require applicants to disclose any previous offences at point of application as some unspent convictions may mean we are unable to proceed with your application due to the nature of our work in healthcare.
Remote Work :
No
Employment Type :
Fulltime
Key Skills
Laboratory Experience,Immunoassays,Machine Learning,Biochemistry,Assays,Research Experience,Spectroscopy,Research & Development,cGMP,Cell Culture,Molecular Biology,Data Analysis Skills
Experience:years
Vacancy:1
