Company Overview
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people’s lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, focusing our efforts on accelerating assets that meet patients’ needs and have the highest probability of success. By uniting science, technology, and talent, we are committed to getting ahead of disease together.
Job Purpose
The Department of Clinical Pharmacology and Quantitative Medicine (CPQM) in Respiratory, Immunology and Inflammation Research Unit, R&D GSK is recruiting for a Director-level Quantitative Systems Pharmacologist Lead to join the Quantitative Systems Pharmacology team. The CPQM at GSK is a newly established organization with the remit to become a Centre of Excellence in Model-Informed Drug Development (MIDD). It uniquely integrates clinical pharmacology, digital medicine, translational imaging, and mechanistic & systems modeling. This position represents a key opportunity for professionals with PhD, MD, PharmD or equivalent doctoral background, who are experienced mechanistic modelers with experience in QSP and/or QST modelling, clinical pharmacology and pharmacometrics to advance the vision and mission of GSK’s rapidly expanding Respiratory, Inflammation and Immunology Disease portfolio. Sought after experiences for this position include building mechanistic mathematical models and leveraging knowledge in scientific ML, inverse problems, AIML and/or statistical methodologies to enhance model robustness for decision-making from exploratory research through clinical development. You will be expected to play a critical role in driving end-to-end model-informed drug discovery and development through building and applying QSP and QST models, defining and coordinating QSP and QST related Clinical Pharmacology and Quantitative Medicine development strategies for disease and therapeutics of interest, and providing expert input into clinical pharmacology evidence generation and integrated evidence plans in the Disease therapeutic area.
This is an exciting opportunity to bring your vision and leadership to a new era of digital innovation in clinical pharmacology and quantitative medicine, profoundly impacting patient outcomes and shaping the future of R&D at GSK.
Key Responsibilities
- Build and/or guide mathematical model development to understand disease, its progression, and drug action to prevent, treat and cure diseases; conduct simulations to assess trial design performance
- Apply mechanistic models of biological, physiological, and pathophysiological processes to evaluate disease pathways, progression, and drug candidates or treatment modalities
- Develop and/or utilize state-of-the-art mathematical tools including inverse-problem modelling and simulation, scientific ML and/or statistical techniques to gain insight into causal relationships between components of system-level and drug-level responses
- Define and execute a coordinated scientific and technical strategy (18-24 months planning horizon) with demonstrated ability to coordinate outputs from several expertise areas to determine strategy
- Collaborate with biologists, clinicians, clinical pharmacologists, pharmacometricians, statisticians, AIML, imaging, biomarker and other partner line colleagues to inform research and development programs and improve understanding of disease mechanisms
- Implement best practices and lessons learned to further clinical pharmacology modelling and simulation contributions to the R&D pipeline
- Create a collaboration framework with internal and external experts in development and application of these models
- Learn and apply emerging modeling and simulation methodologies to enhance clinical program efficiency and investment decision quality; collaborate with external field-leading teams for methodology application
- Interact effectively with line and middle management, staff and external contacts on functional, strategic and tactical levels
- Represent QSP CPQM on internal advisory boards and leadership teams
- Promote transparency and communicate R&D achievements through publications in appropriate scientific journals
Why you?
Basic Qualifications:- PhD, MD, or PharmD with experience in mechanistic modelling and simulation and systems biology with applications in pharmaceutical R&D
- Substantial experience in mechanistic mathematical modeling, inverse problem modeling and simulation, and/or scientific machine learning methodologies in drug development
- Strong drive and agility to quickly learn and build knowledge on a drug-disease system, mechanisms, endpoints, progression, prevention, treatments, and trial design
- Demonstrated aptitude for productive collaboration in a multi-disciplinary team with effective communication and accountability for timely results
- Ability to make sound judgments in complex situations and adapt to changing business needs by prioritizing multiple tasks
- Experience working with senior stakeholders in a cross-functional environment
- Track record of implementing Model-Informed Drug Discovery and Development (MIDD) approaches to accelerate patient access to therapies and expand indications
Preferred Qualifications:- Prior experience in Respiratory, Hepatology and/or Infectious diseases is a plus
GSK is an Equal Opportunity Employer. This ensures that all qualified applicants receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information, military service or any basis prohibited under law.
We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.
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