Job description
Site Name:UK - Hertfordshire - Stevenage
Posted Date:Dec 11 2024

Accountablefor providing laboratory technicalsupportandutilizingspecialist advanced cellular modelling techniques to generate data thathelpselucidate mechanisms of toxicity, understand species differences,identifynovel translational safety biomarkers, and informproject decisions. With a solid background in cell culture and advancedcellular models (such as Complex In Vitro Models, Micro Physiological Systems, and/or Organ on Chip models), the scientist will carry out both paper and laboratory-based studies to support predictive, mechanistic, and translational toxicological investigations across new drug modalities, including Oligos, ADCs, and T-Cell Engagers for projects in discovery and development. Additionally, the scientist will offer subject matterexpertisein specific technical or scientific areas, such asparticularorgan toxicities and cell model techniques. 

We create a place where people can grow, be their best, be safe, and feel welcome,valuedand included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. 

Discover more about our company wide benefits and life at GSK on our webpageLife at GSK | GSK 

Key responsibilities,  

• Independently selects,designsand executes innovative investigative toxicologyexperiments or technical work programs to support Project Issues with minimal supervision; work includes study planning, experiment organization, sample preparation, data generation, processing analysis and reporting. Plans next steps based on interpretation of results.  

• Contributes to establishment and maintenance of scientifically current,state-of-the-artlaboratory environment. 

• Initiatesnew research directions in cellular toxicology and leads development of new cellular assay formats/techniques (from tissues, primary cells, or cell culture systems) for the investigation of mechanisms and translation of organ and cellular toxicities and safety risks to the clinic, including routine mammalian cell screening assays (e.g., cell mutation). 

• Provide high quality data, acceptable toappropriate principlesof data integrity (DI), including quality control (QC) of study data. 

• Be a Subject Matter Expert (SME)in your field,with extensive theoretical and technical understandingandprovideexpert advice to Project Teams, advisory Safety Panels, Target SafetyReviewsand external partners etc asrequired. 

• Where needed understand the disease target under investigation, and if applicable the therapeutic area, and the programme/project plan and potential safety issues of assigned projects / studies. 

• Prepare detailed oral or written reports within agreed timelines. 

Why you? 

Basic Qualifications:  

We are looking for professionals with these required skills to achieve our goals, 

• MSc or PhD or equivalent by experience inCellular biology,Molecularbiology,Toxicologyand/or other related biological science 

• Extensive knowledge of andproficiencyinuse ofmultipleadvancedinvitrocellmodeltechniquesand how to interpret and contextualise data forthepurpose of risk assessment, ideally within a Pharmaceutical orResearch Institute setting. Subject matterexpertisefora specific technical area,related toin vitrocellular models, oraparticularorgantoxicity (liver, kidney, bone marrow), etc. 

• Proficiencyin laboratory and in silico techniques to build and implement new human relevant cell models or other assays to fill strategic gaps and meet Project needs;ideallywith a focuson large molecules(Oligos, ADCs, and T-Cell Engagers etc). 

• Familiarwith platform data and bioinformatics software and working with dataanalysts/bioinformaticians toleveragehigh content data approaches to supporttoxicological MOA and risk assessment. 

• Excellent written and verbal communication and organisational skills, ideally with evidence of a relevant publication record. 

• Ability to work routinely across boundaries as part of cross functional matrix teams internally (e.g., withGeneticToxicology& Molecular safetyandothers inPre-Clinical Scienceand Project Teams) and potentially externally (inc. authorship and presentation of scientific content). 

Preferred Qualifications: 

If you have the following characteristics, it would be a plus, 

• Have experience of providing technical subject matterexpertisetodrug developmentProject Teams,Safety Project Specialists, and other stakeholders, including provision of integrated assessments of pre-clinical toxicity data to supportcommitment toCandidate Selectionor First Time in Human  

• Experienceof the use of in silico modelling platform applicationsor languages (e.g. Matlab or coding in R)with the potential to support adverse outcome pathways and translation of non-clinical data totheclinicalsettingand across species to humans. 

Closing Date for Applications –2ndJanuary2025(COB)  

Please take a copy of the Job Description, as this will not be available post closure of the advert.  
When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. 

At GSK, we have bold ambitions for patients, aiming to positivelyimpactthe health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, humanbiologyand disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D.We’reuniting science,technologyand talent to get ahead of disease together. 

Find out more: 

Our approach to R&D.    

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).

Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.

As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class*(*US only).

We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are.

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